Methotrexate
EQUIVALENT US BRAND NAME: Methotrexate
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We will deliver the Indian brand medicine based on availability.
Product Introduction:
Methotrexate is a medication classified as an antimetabolite and antifolate drug. It was first introduced in the 1950s as a chemotherapy agent primarily for the treatment of cancer, particularly leukemias, lymphomas, and certain solid tumors. Over time, it has also become widely used in lower doses to treat autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease (Crohn’s disease and ulcerative colitis).
Uses:
- Cancer Treatment: Methotrexate is used in high doses to treat various types of cancer, including leukemia, lymphoma, breast cancer, lung cancer, and others.
- Autoimmune Diseases: In lower doses, methotrexate is used to treat autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease (Crohn’s disease and ulcerative colitis).
Benefits:
- Effective in treating various forms of cancer and autoimmune diseases.
- Can help manage symptoms and improve quality of life for patients with these conditions.
- Methotrexate is often more affordable compared to newer biologic agents used for similar conditions.
Side Effects:
- Nausea and Vomiting: Common side effects include gastrointestinal symptoms such as nausea, vomiting, and loss of appetite.
- Bone Marrow Suppression: Methotrexate can suppress bone marrow function, leading to decreased production of red blood cells, white blood cells, and platelets, which may increase the risk of anemia, infection, and bleeding.
- Liver Toxicity: Liver function abnormalities can occur, necessitating regular monitoring of liver enzymes.
- Pulmonary Toxicity: Rarely, methotrexate can cause lung inflammation (pneumonitis).
- Teratogenicity: Methotrexate is contraindicated during pregnancy due to its potential to cause birth defects.
Safety Advice:
- Patients taking methotrexate should be closely monitored by healthcare providers for potential side effects and toxicity.
- Regular blood tests to monitor blood cell counts and liver function are essential.
- Methotrexate should be used with caution in patients with liver or kidney impairment.
- Avoid alcohol consumption while taking methotrexate, as it can increase the risk of liver toxicity.
- Women of childbearing age should use effective contraception while taking methotrexate, and men should use contraception during treatment and for a period afterward due to the drug’s teratogenic effects.
Interaction with Drugs:
- Methotrexate may interact with a variety of medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), certain antibiotics, and other drugs that affect liver function or the kidneys.
- Concurrent use of methotrexate with drugs that also suppress bone marrow function can increase the risk of myelosuppression.
- It’s crucial for healthcare providers to review a patient’s medication list thoroughly to identify potential interactions before prescribing methotrexate.
More Information:
For more detailed information on methotrexate, including dosage, precautions, and patient education materials, please refer to the MedlinePlus page on Methotrexate.
This information serves as a general overview and should not replace professional medical advice. Patients should always consult their healthcare provider for personalized guidance regarding their treatment.
Note :
- Do not put the quantity above 30 days. (eg. if prescription is 2 pills per day then you can purchase one month of supply of 60 pills)
- We will deliver medicine of Indian brand within 30 days of supply.
- Prescription and ID are required to purchase each Month of supply.
- If a doctor writes 30 days of medicines with 3 times refills then you can use the same prescription for 3 consecutive months for purchasing medicine using reorder option and uploading the same prescription and your ID 3 times.